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Sixteen compounds of N-aroyl-N’’-(4’’-alkoxyphenyl) thiourea derivative, twenty one compounds of N-aroyl-N’’-(3’’-hydroxy-4’’-alkoxycarbonylphenyl) thiourea derivative, three compounds of N-aroyl-N’-alpha-naphthylthiourea derivative and three compounds of N-cyanoacetyl-N’’-aroyl thiosemicarbazide derivative were synthesized as potential antitubercular agent and were subjected to screening . test for antitubercular activity against Mycobacterium tuberculosis H37Rv by tube dilution method in vitro. Of the forty three compounds, N-p-cyanobenzoyl-N’’-(4’’- iso-butoxyphenyl) thiourea, N-p-cyanobenzoyl-N’’-(4’’-n-amoxyphenyl)thiourea, N-furoyl-N’’-(4’’-n-amoxyphenyl) thiourea, N-p-cyanobenzoyl-N’’-(3’’-hydroxy-4’’-ethoxycarbonylphenyI)thioureal N-p-cyanobenzoyl-N’’-(3’’-hydroxy-4’’-n-butoxycarbonylphenyl)thiourea, N-p-cyanobenzoyl-N’’-(3’’-hydroxy-4’’-n-amoxycarbonylphenyl)thiourea, N-p-cyanobenzoyl-N’’-(3’’-hydroxy-4’’-iso-amoxycarbonylphenyl)thiourea, and N-5-nitrofuroyl-N’’(3’’-hydroxy- 4’’-n-amoxycarbonylphenyl)thiourea showed the growth inhibition of M. tuberculosis H37Rv at the concentration of 10mcg/ml, respectively.
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